Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo [3, 4-d] pyrimidines as novel mGluR4 positive …

…, EP Lebois, Q Luo, K Kim, H Muchalski, H Yin…

Index: Niswender, Colleen M.; Lebois, Evan P.; Luo, Qingwei; Kim, Kwangho; Muchalski, Hubert; Yin, Huiyong; Conn, P. Jeffrey; Lindsley, Craig W. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5626 - 5630

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Citation Number: 47

Abstract

This letter describes the synthesis and SAR, developed through an iterative analogue library approach, of an mGluR4 positive allosteric modulator lead based on a pyrazolo [3, 4-d] pyrimidine scaffold. Despite tremendous therapeutic potential, Compound 7, VU0080421, and related congeners represent only a handful of mGluR4 positive allosteric modulators ever described.