Development of a scaleable synthesis of a 3-aminopyrazinone acetamide thrombin inhibitor

MS Ashwood, RJ Alabaster, IF Cottrell…

Index: Organic Process Research and Development, , vol. 8, # 2 p. 192 - 200

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Citation Number: 6

Abstract

... Organic Process Research & Development. ... The use of low-temperature reactions, fluorinating agents, and sodium azide had all been removed from the process. ... Following this procedure, glycine ethyl ester 21 was acylated with ethyl oxalyl chloride 20 (2.0 equiv) at 0 °C under ...

Development of a scaleable synthesis of a 3-aminopyrazinone ...

[Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D. Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200]

Tetrabutylammonium salt induced denitration of nitropyridine...

[Organic Letters, , vol. 7, # 4 p. 577 - 579]