Advanced Synthesis & Catalysis

Novel, Stereoselective and Stereospecific Synthesis of Allenylphosphonates and Related Compounds via Palladium??Catalyzed Propargylic Substitution

M Kalek, J Stawinski

Index: Kalek, Marcin; Stawinski, Jacek Advanced Synthesis and Catalysis, 2011 , vol. 353, # 10 p. 1741 - 1755

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Citation Number: 21

Abstract

Abstract We have developed a novel method for the synthesis of allenylphosphonates and related compounds based on a palladium (0)-catalyzed reaction of propargylic derivatives with H-phosphonate, H-phosphonothioate, H-phosphonoselenoate, and H-phosphinate esters. The reaction is stereoselective and stereospecific, and provides a convenient entry to a vast array of allenylphosphonates and their analogues with diverse substitution patterns ...