Synthesis of 2′-deoxy-5-monofluoromethyluridine (FTDR) and 2′-deoxy-5-difluoromethyluridine (F 2 TDR)

J Matulic-Adamic, KA Watanabe

Index: Matulic-Adamic, Jasenka; Watanabe, Kyoichi A. Journal of the Chemical Society, Chemical Communications, 1985 , # 21 p. 1535 - 1536

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Citation Number: 3

Abstract

The synthesis of potential anticancer and antitumour nucleosides, 2′-deoxy-5- monofluoromethyluridine (FTDR) and 2′-deoxy-5-difluoromethyluridine (FTDR) was achieved in four steps from thymidine including monosilylation with t-butyldiphenylsilyl chioride, photochemical brominatio, followed by AgF treatment and subse