Efficient, stereocontrolled total syntheses of racemic and natural brefeldin-A

C Le Drian, AE Greene

Index: Drian, Claude Le; Greene, Andrew E. Journal of the American Chemical Society, 1982 , vol. 104, # 20 p. 5473 - 5483

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Citation Number: 92

Abstract

Abstract: Brefeldin-A, an antibiotic fungal metabolite, has been obtained in both racemic and natural forms through a direct approach that employs norbornenone and 6-heptyn-2-01 as the basic starting materials. ... Brefeldin-A (as decumbin) was first isolated in 1958 from Penicillium decumbens by Singleton, Bohonos, and Ullstrup.la The metabolite has subsequently been found in cultures of Pen- icillium cyaneum,lb Penicillium brefeldianum,lc and Ascochyta ...