The directed Pauson-Khand reaction

ME Krafft, CA Juliano, IL Scott, C Wright…

Index: Krafft, Marie E.; Juliano, Carmelinda A.; Scott, Ian L.; Wright, Colin; McEachin, Michael D. Journal of the American Chemical Society, 1991 , vol. 113, # 5 p. 1693 - 1703

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Citation Number: 81

Abstract

Abstract: The regioselectivity of the cobalt-mediated cocyclization of an alkene, an alkyne, and carbon inonoxidc has bccn shown to bc dircctcd by the use of a soft atom, either sulfur or nitrogen, tethered to the alkene partner by a carbon chain. Direction from the homoallylic position is more efficient than from the allylic or bishomoallylic position. A rationale is proposed to explain this observation. Studies on the effect of different alkyl groups on the ...