Tetrahedron

Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

…, H Yasmin, MM Masud, SC Roy, L Nahar, MM Rahman…

Index: Das, Sharmistha; Yasmin, Hasina; Mehedi Masud; Roy, Suvas C.; Nahar, Lutfun; Mukhlesur Rahman; Gibbons, Simon; Bachar, Sitesh C.; Sarker, Satyajit D. Tetrahedron, 2008 , vol. 64, # 37 p. 8642 - 8645

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Citation Number: 10

Abstract

6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3- fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6- fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid ...