4H-Benzo [4, 5] cyclohepta [1, 2-b] thiophenes and 9, 10-dihydro derivatives-sulfonium analogues of pizotifen and ketotifen; chirality of ketotifen; synthesis of the 2- …

…, M Buděšínský, J Holubek, B Schneider…

Index: Polivka, Zdenek; Budesinsky, Milos; Holubek, Jiri; Schneider, Bohdan; Sediva, Zdenek; et al. Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 9 p. 2443 - 2469

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Citation Number: 13

Abstract

Abstract Reaction of ketone IX with 4-tetrahydrothiopyranylmagnesium bromide and the following dehydration with thionyl chloride afforded the sulfide III which was transformed to the methiodide II (sulfonium analogue of pizotifen). Similar sequence starting from the ketone XXIV and concluded by dehydration of the alcohol XX, cleavage of the enol ether, and by treatment with methyl iodide resulted in the formation of the sulfonium analogue of ...