The Journal of Organic Chemistry

Enynones in Organic Synthesis. 8. Synthesis of the Antimicrobial-Cytotoxic Agent Juncusol and Members of the Effusol Class of Phenols

PA Jacobi, JI Kravitz, W Zheng

Index: Jacobi, Peter A.; Kravitz, Joseph I.; Zheng, Wanjun Journal of Organic Chemistry, 1995 , vol. 60, # 2 p. 376 - 385

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Citation Number: 17

Abstract

Two new syntheses of phenols have been developed which have been utilized in an efficient preparation of the antimicrobial-cytotoxic agent juncusol (22) and several members of the effusol (23) class of phenols. These results complement our earlier studies with enynones of type 42 and provide for the highly efficient conversion of 42 to either methylenecyclopentenones 45 or phenols of type 47 or 54 with virtually 100% selectivity.