e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
Efficient one-pot synthesis of β-hydroxyphosphonates: regioselective nucleophilic ring opening reaction of epoxides with triethyl phosphite catalyzed by Al (OTf) 3
A variety of β-hydroxyphosphonates were produced in high yields by ring opening reaction of different types of epoxides with di/trialkyl phosphite esters catalyzed by Al (OTf) 3. The reactions proceeded with complete chemo-and regioselectivity to give the title compounds. This method is new, simple and efficient for the one-pot synthesis of β-hydroxyphosphonates via direct C–P bond formation.
