A new route to tetrazole-derived cyclic amines based on the TMSN3-modified Ugi reaction with 2-substituted cyclic imines was elaborated. The reaction allows the direct preparation of five-, six-, and seven-membered cyclic amines substituted with a tetrazole ring, which are important types of organocatalysts. The scope and limitations of this method are discussed. In the case of the Ugi reaction with benzyl isocyanide, the N-substituted tetrazoles can be ...
[El-Ahl, Abdel-Aziz S.; Amer, Fatty A.; Elbeheery, Akram H. Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 11 p. 2226 - 2235]
