Farmaco

Non-steroidal antiinflammatory agents. Synthesis and enzyme inhibition of 2-[4-(heteroarylmethyl) phenyl] propanoic acids and analogues

R Silvestri, E Pagnozzi, M Valoti, F Fusi

Index: Silvestri; Pagnozzi; Valoti; Fusi Farmaco, 1994 , vol. 49, # 10 p. 625 - 632

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Citation Number: 2

Abstract

Abstract Some 2-[4-(heteroarylmethyl) phenyl] propanoic acids and phenylacetic and benzoic analogues have been synthesized. All above acids were tested for their inhibitory activity on lipoxygenase and cyclooxygenase, in comparison with NDGA and tolmetin. 2-[4- (Thien-2-ylmethyl) phenyl] propanoic acid 2, strictly related with suprofen, was found the most interesting compund, giving rise to a 79% inhibition of the cyclooxygenase activity at ...