Organic letters

Synthesis of biphenyl-2-carbonitrile derivatives via a palladium-catalyzed sp2 C− H bond activation using cyano as a directing group

W Li, Z Xu, P Sun, X Jiang, M Fang

Index: Li, Wu; Xu, Zhipeng; Sun, Peipei; Jiang, Xiaoqing; Fang, Min Organic Letters, 2011 , vol. 13, # 6 p. 1286 - 1289

Full Text: HTML

Citation Number: 63

Abstract

Aromatic nitriles possess versatile utilities and are indispensible not only in organic synthesis but also in the chemical industry.(1) In fact, the nitrile group is an important precursor for various functional groups such as aldehydes, amines, amidines, tetrazoles, amides, and their carboxyl derivatives.(2) In addition, biphenyls represent a key structural motif in a large number of compounds used as pharmaceuticals, agrochemicals, dyes, chiral ligands for metal catalysts, liquid ...