Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation

…, JH Ryu, R Jeon, EH Kim, SJ Hwang…

Index: Han, Chang Yeob; Ki, Sung Hwan; Kim, Young Woo; Noh, Kyoung; Lee, Da Yeon; Kang, Bomi; Ryu, Jae-Ha; Jeon, Raok; Kim, Eun Hyun; Hwang, Se Jin; Kim, Sang Geon Antioxidants and Redox Signaling, 2011 , vol. 14, # 2 p. 187 - 202

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Citation Number: 25

Abstract

Abstract Hepatic steatosis, a hepatic component of metabolic syndrome, is common and may progress to steatohepatitis and cirrhosis. The liver X receptor-α (LXRα)-sterol regulatory element binding protein-1c (SREBP-1c) pathway plays a key role in hepatic steatosis. This study investigated the potential of ajoene, a stable garlic by-product, to inhibit high fat diet (HFD)-induced hepatic steatosis and the underlying mechanism. Ajoene treatment ...