Convenient Synthesis of 5, 6, 7, 8-Tetrahydroquinolin-8-ylamine and 6, 7-Dihydro-5 H-quinolin-8-one

EJ McEachern, W Yang, G Chen, RT Skerlj…

Index: McEachern; Yang; Chen; Skerlj; Bridger Synthetic Communications, 2003 , vol. 33, # 20 p. 3497 - 3502

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Citation Number: 7

Abstract

A novel two-step synthesis of 5,6,7,8-tetrahydroquinolin-8-ylamine, involving regioselective nitrosation of 5,6,7,8-tetrahydroquinoline followed by oxime reduction, is described. Oxime hydrolysis affords 6,7-dihydro-5H-quinolin-8-one. ... A novel two-step synthesis of 5,6,7,8-tetrahydroquinolin-8- ylamine, involving regioselective nitrosation of 5,6,7,8-tetrahydroquinoline followed by oxime reduction, is described. Oxime hydrolysis affords 6,7-dihydro-5H-quinolin-8-one.

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