Abstract Quantitative gas chromatographic analysis of the 3-hydroxyisothiazole product distributions formed in the chlorine induced cyclization of 3, 3′-dithiodipropionamide and 3- mercaptopropion-arnide has led to reaction conditions which yield respectively 3- hydroxyisothiazole, 5-chloro-3-hydroxyisothiazole, or 4, 5-dichloro-3-hydroxyisothiazole as the predominant product. The 4-chloro analog was found in only small quantity. Similar glc ...
[Dekker, Frank J.; Ghizzoni, Massimo; van der Meer, Nanette; Wisastra, Rosalina; Haisma, Hidde J. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 2 p. 460 - 466]
