2-Trihalogenomethylbenzazoles. Part IV. Reactions with difunctional nucleophiles. Formation of heterocyclic rings on the 2-position of benzazoles

BC Ennis, G Holan, EL Samuel

Index: Ennis,B.C. et al. Journal of the Chemical Society [Section] C: Organic, 1967 , p. 33 - 39

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Citation Number: 11

Abstract

The reaction of selected 2-trihalogenomethylbenzimidazoles with 1, 2-difunctional amines, amino-alcohols, and amino-thiols formed benzimidazoles substituted on the 2-position with 2-imidazolin-2-yl, 2-oxazolin-2-yl, and 2-thiazolin-2-yl rings. This high-yield method was extended to the formation of six-and seven-membered-ring analogues by the reaction of the trihalogenomethyl group with 1, 3-and 1, 4-difunctional nucleophiles. Similarly, aromatic ...