Tetrahedron letters

Synthesis of new chiral diphosphine ligand (BisbenzodioxanPhos) and its application in asymmetric catalytic hydrogenation

CC Pai, YM Li, ZY Zhou, ASC Chan

Index: Pai, Cheng-Chao; Li, Yue-Ming; Zhou, Zhong-Yuan; Chan, Albert S.C Tetrahedron Letters, 2002 , vol. 43, # 15 p. 2789 - 2792

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Citation Number: 84

Abstract

The new chiral diphosphine ligand [(5, 6),(5′, 6′)-bis (1, 2-ethylenedioxy) biphenyl-2, 2′- diyl] bis (diphenylphosphine)(BisbenzodioxanPhos) has been successfully prepared and used in ruthenium-catalyzed asymmetric hydrogenation of 2-(6′-methoxy-2′-naphthyl) propenoic acid and β-keto esters with high enantioselectivity (92.2% and up to 99.5% ee, respectively).