Synthesis of 18F-labelled 2-fluoroethyl-nitrosoureas

…, M Diksic, LY Yamamoto, W Feindel

Index: Farrokhzad; Diksic; Yamamoto; Feindel Canadian Journal of Chemistry, 1984 , vol. 62, # 11 p. 2107 - 2112

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Citation Number: 21

Abstract

18F-labelled 1, 3-bis-(2-fluoroethyl) nitrosourea (18F-BFNU)(9) and 1-(2-chloroethyl)-3-(2- fluoroethyl) nitrosourea (18F-CFNU)(isomeric mixture, 11, 12) were synthesized by nucleophilic attack of 18F-labelled tetra-n-butylammonium fluoride on the aziridine ring of 1, 3-substituted ureas. Diethyleneurea (DEU)(5), 1-(2-fluoroethyl)-3-ethyleneurea (FEU)(7), and 1-(2-chloroethyl)-3-ethyleneurea (CEU)(14) were used as starting materials in the ...