e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Org. Process Res. Dev
Development of safe, scalable nitric acid oxidation using a catalytic amount of NaNO2 for 3-Bromo-2, 2-bis (bromomethyl) propanoic acid: an intermediate of s-013420
H Osato, M Kabaki, S Shimizu
Index: Osato, Hiroshi; Kabaki, Mikio; Shimizu, Sumio Organic Process Research and Development, 2011 , vol. 15, # 3 p. 581 - 584
ABSTRACT: A safe, scalable process was developed for nitric acid oxidation of 3-bromo-2, 2- bis (bromomethyl) propan-1-ol (2) to give 3-bromo-2, 2-bis (bromomethyl) propanoic acid (3), an intermediate in the synthesis of S-013420 (1). The key points are the use of a catalytic amount of NaNO2 and addition of the starting material in portions. We achieved 3,000 L scale pilot production.