e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Optically Active Aromatic and Heteroaromatic α-Amino Acids by a One-Pot Catalytic Enantioselective Addition of Aromatic and Heteroaromatic CH Bonds to α-Imino …
…, P Bayón, PS Aburel, KA Jørgensen
Index: Saaby, Steen; Bayon, Pau; Aburel, Pompiliu S.; Jorgensen, Karl Anker Journal of Organic Chemistry, 2002 , vol. 67, # 12 p. 4352 - 4361
The development of a practical one-pot catalytic enantioselective procedure for the synthesis of non-natural aromatic and heteroaromatic α-amino acids is reported. Starting from readily available starting materials and application of a chiral BINAP-Cu (I) catalyst, the optically active products are formed with readily removable N-protecting groups. The scope of the reaction is demonstrated by the addition of substituted furans, thiophenes, pyrroles, ...
