Abstract Vinylogously extended deoxyeritadenine derivatives were synthesized as acyclic/carbocyclic analogues of the 6′-halo (homovinyl) adenosines, which are known to be potent inhibitors of S-adenosyl-l-homocysteine hydrolase. Swern oxidation of 9-[3-(t- butyldimethylsilyloxy)-4-hydroxybutyl] adenine (4) followed by Wittig olefination and desilylation gave access to ethyl 6-(adenin-9-yl)-4-hydroxy-2 (E)-hexenoate (7) and 5-( ...
![9-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]purin-6-amine Structure](https://image.chemsrc.com/caspic/001/55559-78-9.png)
