Advanced Synthesis & Catalysis

Mechanistic Switch via Subtle Ligand Modulation: Palladium??Catalyzed Synthesis of α, β??Substituted Styrenes via C H Bond Functionalization

A Flores??Gaspar, R Martin

Index: Flores-Gaspar, Areli; Martin, Ruben Advanced Synthesis and Catalysis, 2011 , vol. 353, # 8 p. 1223 - 1228

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Citation Number: 14

Abstract

Abstract A new catalyst system able to efficiently perform the synthesis of styrenes via C [BOND] H bond functionalization and a subtle ligand modification are described. The high level of activity achieved allows for the synthesis of highly functionalized α, β-substituted styrenes, even the elusive E-configured trisubstituted olefins, in a regio-and stereoselective manner. Mechanistic experiments allowed for the identification of the corresponding ...