Abstract A new route via iodine catalysed heterocyclisation of 2-amino-4, 5- dimethylthiophene-3-carboxamide with aromatic aldehydes affording a series of thieno [2, 3- d] pyrimidine derivatives in a single step have been developed. Some of these compounds exhibited antibacterial activities comparable to Streptomycin as reference drug.
![2-(4-methoxyphenyl)-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one Structure](https://image.chemsrc.com/caspic/095/60442-57-1.png)
