Tetrahedron

FeCl 3· 6H 2 O-promoted skeleton-rearrangement of 1-substituted-3-benzazepines: substrate extension and product utilization

J Zhang, K Wu, M Wang, J Jiang, A Zhang

Index: Zhang, Jing; Wu, Kui; Wang, Meining; Jiang, Jianqin; Zhang, Ao Tetrahedron, 2011 , vol. 67, # 5 p. 842 - 848

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Abstract

FeCl3· 6H2O-promoted skeleton-rearrangement of 1-substituted-3-benzazepines was further exploited. Both 1-aryl-and 1-alkyl-or 1-alkenyl-benzazepines underwent this reaction smoothly. The rearrangement products were used to prepare a series of novel derivatives containing both tetrahydroisoquinoline (THIQ) and tetrahydropyrimidin-4 (1H)-one scaffolds through a Mannich-type process.