Tetrahedron letters

Cyclic ketones and substituted α-keto acids as alternative substrates for novel Biginelli-like scaffold syntheses

MM Abelman, SC Smith, DR James

Index: Abelman, Matthew M.; Smith, Stephen C.; James, Donald R. Tetrahedron Letters, 2003 , vol. 44, # 24 p. 4559 - 4562

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Citation Number: 78

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The reactions of benzocyclic ketones and α-ketoacids as carbonyl components in the Biginelli reaction were investigated. These unusual Biginelli substrates furnished novel drug-like dihydropyrimidinone scaffolds suitable for further elaboration. ... The prototypical Biginelli reaction. The ...