Tetrahedron Letters

Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

B Ilkgul, D Gunes, O Sirkecioglu, N Bicak

Index: Ilkgul, Baris; Gunes, Deniz; Sirkecioglu, Okan; Bicak, Niyazi Tetrahedron Letters, 2010 , vol. 51, # 40 p. 5313 - 5315

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Citation Number: 18

Abstract

A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75–94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240–260° C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.