Tetrahedron

Exploiting microwave-assisted neat procedures: Synthesis of N-aryl and N-alkylnitrones and their cycloaddition en route for isoxazolidines

MM Andrade, MT Barros, RC Pinto

Index: Andrade, Marta M.; Barros, Maria Teresa; Pinto, Rui C. Tetrahedron, 2008 , vol. 64, # 46 p. 10521 - 10530

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Citation Number: 35

Abstract

Microwave irradiation allows increasing the speed of several reactions and also offers the possibility of eliminating poisoning organic solvents. In this work we report the microwave- assisted neat synthesis of α-phenyl-tert-butylnitrone (PBN) and other alkyl and aryl nitrones and also the rapid synthesis of isoxazolidines resulting from 1, 3-dipolar cycloaddition of nitrones to ethyl trans-crotonate.