Tetrahedron

The synthesis of ketolide antibiotic ABT-773 (cethromycin)

DJ Plata, MR Leanna, M Rasmussen, MA McLaughlin…

Index: Plata, Daniel J.; Leanna, M. Robert; Rasmussen, Michael; McLaughlin, Maureen A.; Condon, Steven L.; Kerdesky, Francis A.J.; King, Steven A.; Peterson, Matthew J.; Stoner, Eric J.; Wittenberger, Steven J. Tetrahedron, 2004 , vol. 60, # 45 p. 10171 - 10180

Full Text: HTML

Citation Number: 31

Abstract

A practical and efficient synthesis of ketolide antibiotic cethromycin (ABT-773)() is described. An effective protection strategy allows high yielding, regioselective C6-O-alkylation and subsequent stereoselective modification of the erythromycin nucleus. ABT-773 was prepared in 10 steps from commercially available erythromycin A oxime.