Bioorganic Chemistry

Synthesis and use of deuterated 3, 4-dihydroxyphenylglycolaldehyde as an internal standard for determination of DOPEGAL in brain tissue by gas chromatography– …

SW Li, VT Spaziano, WH Elliott, WJ Burke

Index: Li, Shu Wen; Spaziano, Vincent T.; Elliott, William H.; Burke, William J. Bioorganic Chemistry, 1996 ,  vol. 24,  # 2  p. 169 - 177

Full Text: HTML

Citation Number: 5

Abstract

Trideuterated 3, 4-dihydroxyphenylglycolaldehyde (DOPEGAL-d3) was synthesized from tetradeuterated catechol. After derivatization withN-methyl-N-trimethylsilyltrifluoroacetamide, the identity of DOPEGAL-d3was confirmed by comparison with unlabeled DOPEGAL by gas chromatography–mass spectrometry (GC–MS); they have the same pattern of mass fragmentation. The deuterated DOPEGAL was used as an internal standard for the ...