The Journal of organic chemistry

Intramolecular Nicholas reactions in the synthesis of dibenzocycloheptanes. synthesis of allocolchicine NSC 51046 and analogues and the formal synthesis of (−)- …

S Djurdjevic, F Yang, JR Green

Index: Djurdjevic, Sinisa; Yang, Fei; Green, James R. Journal of Organic Chemistry, 2010 ,  vol. 75,  # 23  p. 8241 - 8251

Full Text: HTML

Citation Number: 29

Abstract

The preparation of dibenzocycloheptyne-Co2 (CO) 6 complexes by intramolecular Nicholas reactions of biaryl-2-propargyl alcohol-Co2 (CO) 6 derivatives is described. Reductive decomplexation of the dibenzocycloheptyne-Co2 (CO) 6 complexes affords the corresponding dibenzocycloheptenes, individual members of which have been employed in a formal total synthesis of (−)-allocolchicine, the preparation of 6, 7-dihydro-3, 4, 9, 10, 11- ...