Abstract The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation—opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments C 7–C 12 and C 13–C 21 in the target molecule.
![2-{(7S)-5,5-dimethyl-4,6-dioxaspiro[2.5]oct-7-yl}-2-methylpentan-3-one Structure](https://image.chemsrc.com/caspic/357/1236206-59-9.png)
