Tetrahedron

Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective …

…, HI Boshoff, D Tasdemir, R Perozzo, M Kaiser, F Wang…

Index: Giddens, Anna C.; Nielsen, Lone; Boshoff, Helena I.; Tasdemir, Deniz; Perozzo, Remo; Kaiser, Marcel; Wang, Feng; Sacchettini, James C.; Copp, Brent R. Tetrahedron, 2008 , vol. 64, # 7 p. 1242 - 1249

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Citation Number: 32

Abstract

Total syntheses of the title natural products, pseudopyronines A (1) and B (2), have been achieved using methyl β-oxo carboxylic ester starting materials. The natural products and a small set of structurally related compounds were evaluated for growth inhibitory activity against a range of pathogenic microorganisms and were found to exhibit good potency (IC50≥ 0.46 μg/mL) and selectivity towards Leishmania donovani. Several of the ...