Ligand design for α 1 adrenoceptor subtype selective antagonists

…, B Coban, R Griffith, KM Groenewoud, BF Yates

Index: Bremner; Coban; Griffith; Groenewoud; Yates Bioorganic and medicinal chemistry, 2000 , vol. 8, # 1 p. 201 - 214

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Citation Number: 84

Abstract

α1 Adrenoceptors have three subtypes and drugs interacting selectively with these subtypes could be useful in the treatment of a variety of diseases. In order to gain an insight into the structural principles governing subtype selectivity, ligand based drug design (pharmacophore development) methods have been used to design a novel 1, 2, 3- thiadiazole ring d analogue of the aporphine system. Synthesis and testing of this ...

The first Bischler–Napieralski cyclization in a room tempera...

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A synthesis of N-formylenamides of isoquinoline

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