Designing dendrimers for ocular drug delivery

…, F Malecaze, CO Turrin, V Soler, C Duhayon…

Index: Spataro, Gregory; Malecaze, Francois; Turrin, Cedric-Olivier; Soler, Vincent; Duhayon, Carine; Elena, Pierre-Paul; Majoral, Jean-Pierre; Caminade, Anne-Marie European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 326 - 334

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Citation Number: 91

Abstract

New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used to treat glaucoma) to afford ion pair (saline) species. The solubility in water of these charged ...