Tetrahedron Letters

Reductive amine deallyl-and debenzylation with alkali metal in Silica Gel (M-SG)

P Nandi, JL Dye, JE Jackson

Index: Nandi, Partha; Dye, James L.; Jackson, James E. Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3864 - 3866

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Citation Number: 6

Abstract

Alkali metals in silica gel (the M-SG materials) are effective reagents for reductive deallylation, debenzylation, debenzhydrylation, and detritylation of amines. As such, these reagents provide a convenient alternative to traditional metal ammonia solutions for this class of deprotections.