Highly selective hydroaminomethylation of internal alkenes to give linear amines

M Ahmed, RPJ Bronger, R Jackstell…

Index: Ahmed, Moballigh; Bronger, Raymond P. J.; Jackstell, Ralf; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.; Beller, Matthias Chemistry - A European Journal, 2006 , vol. 12, # 35 p. 8979 - 8988

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Citation Number: 69

Abstract

Abstract The application of phenoxaphosphino-modified Xantphos-type ligands (1–9) in the rhodium-catalyzed hydroaminomethylation of internal olefins to give linear amines is reported. Excellent chemo-and regioselectivities have been obtained through the use of 0.1 mol%[Rh (cod) 2] BF 4/0.4 mol% xantphenoxaphos (1), providing a practical and environmentally attractive synthetic route for the preparation of amines from internal ...