Photophysical properties of 3-[2-cyano-4-(dimethylamino) phenyl] alanine: a highly fluorescent and environment-sensitive amino acid with small molecular size

J Oshima, H Tsujimoto, T Yoshihara, K Yamada…

Index: Oshima, Juro; Tsujimoto, Hitomi; Yoshihara, Toshitada; Yamada, Keiichi; Katakai, Ryoichi; Tobita, Seiji Chemistry Letters, 2006 , vol. 35, # 6 p. 620 - 621

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Citation Number: 2

Abstract

A new nonnatural amino acid 3-[2-cyano-4-(dimethylamino) phenyl] alanine (CDAPA) is virtually nonfluorescent in water but shows significant enhancement of fluorescence intensity and lifetime when the molecule partitions to nonaqueous environments, suggesting that this molecule is a good candidate as small fluorescent probe for proteins.