e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Journal of fluorine chemistry
Unsaturated nitrogen compounds containing fluorine. Part 9 [1]. The preparation of 2, 5-dichloro-l, l, l, 6, 6, 6-hexafluoro-3, 4-diazahexa-2, 4-diene and its reaction with …
D Bell, AOA Eltoum, NJ O'Reilly, AE Tipping
Index: Bell, David; Eltoum, Ahmed O. A.; O'Reilly, Neil J.; Tipping, Anthony E. Journal of Fluorine Chemistry, 1993 , vol. 64, # 1-2 p. 151 - 166
Abstract 2, 5-Dichloro-1, 1, 1, 6, 6, 6-hexafluoro-3, 4-diazahexa-2, 4-diene (1) has been prepared in goodyield (60%) by the reaction of 1, 2-bis (trifluoroacetyl) hydrazine with a mixture of N, N-dimethylaniline hydrochloride and phosphoryl chloride. Nucleophilic displacement ofchlorine from azine 1 occurs readily on reaction with primary amines RNH 2 (R Pr i, Bu s, Ph, 4-FC 6 H 4, 2, 6-Cl 2 C 5 H 2 NCH 2-4) and with secondary amines ( ...