Steroids

Synthesis of 3β-hydroxy-androsta-5, 7-dien-17-one from 3β-hydroxyandrost-5-en-17-one via microbial 7α-hydroxylation

TG Lobastova, SM Khomutov, LL Vasiljeva…

Index: Lobastova, Tatyana G.; Khomutov, Sergey M.; Vasiljeva, Ljudmila L.; Lapitskaya, Margarita A.; Pivnitsky, Kasimir K.; Donova, Marina V. Steroids, 2009 , vol. 74, # 2 p. 233 - 237

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Citation Number: 15

Abstract

The synthesis of 3β-hydroxy-androsta-5, 7-dien-17-one from 3β-hydroxy-androst-5-en-17- one (dehydroepiandrosterone, DHEA) via microbial 7α-hydroxylation has been accomplished. At the first stage, 3β, 7α-dihydroxy-androst-5-en-17-one was obtained in high yield (71.2%) using a strain of Gibberella zeae VKM F-2600, which was first applied for DHEA conversion. The further route included the substitution of 7α-hydroxyl group with ...