Index: McCall, John M.; TenBrink, R. E.; Kamdar, Bharat V.; Skaletzky, Louis L.; Perricone, Salvatore C.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 133 - 137
A family of 7-(trifluoromethyl)-4-aminoquinoliies that are hypotensive agents and that act by a novel sympatholytic mechanism is described. Structure-activity relationships in this series have been elucidated. Some of the more potent hypotensives were evaluated for safety in the mouse. A candidate, 1-[(4-fluorophenyl) sulfonyl]-4-[4-[[7-(trifluoromethyl)-4-quinolinyl] amino] benzoyllpiperazine hydrochloride (losulazine hydrochloride) has been selected for ...
