Serine and threonine β-lactones: A new class of hepatitis A virus 3C cysteine proteinase inhibitors

MS Lall, YK Ramtohul, MNG James…

Index: Box, Vernon G. S.; Marinovic, Nash; Yiannikouros, George P. Heterocycles, 1991 , vol. 32, # 2 p. 245 - 251

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Citation Number: 96

Abstract

... Volume: Page: ... Despite the absence of the P 1 glutamine side chain important for HAV 3C substrate/inhibitor recognition, β-lactones 5a and 5b are potent ... C to RT, 14% (unoptimized yield) (vi) H 2 , Pd/C, MeOH, 87%; (vii) DMAD, PPh 3 , THF, −78 °C to RT, 32%. ...