Comparative reactivities of mitomycin C, 7-(N-piperidino) mitomycin, and mitomycin A. The role of the C (7) substituent

S Subramaniam, H Kohn

Index: Subramaniam; Kohn Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 10519 - 10526

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Citation Number: 8

Abstract

Abstract: Mitomycin C (la) is considered to be the protypical bioreductive alkylating agent. Enzymatic reduction leads to activation of the two DNA-bonding sites (C (1) and C (10)) in la, permitting the formation of intrahelical interstrand DNA-mitomycin C cross-link adducts. Drug discovery programs have uncovered several C (7) mitomycin analogues that display a superior profile versus la when assayed against a battery of tumor models. The chemical ...