Tetrahedron letters

Synthesis of 4-(cyclic dialkylamino)-7-azaindoles by microwave heating of 4-halo-7-azaindoles and cyclic secondary amines

JJ Caldwell, KM Cheung, I Collins

Index: Caldwell, John J.; Cheung, Kwai-Ming; Collins, Ian Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1527 - 1529

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Citation Number: 17

Abstract

Nucleophilic aromatic substitution of 4-chloro-and 4-fluoro-7-azaindoles with cyclic secondary amines under microwave heating gave a straightforward and rapid synthesis of 4- (cyclic dialkylamino)-7-azaindoles. 4-Fluoro-7-azaindoles showed a greater reactivity towards SNAr reactions under these conditions than 4-chloro-7-azaindole.