The Journal of Organic Chemistry

Some Unusual Reactions of 6-Chloropurines with Thioureas. 6-Alkylthiopurines and 2, 2-Diamino-2H-thiazolo [3, 4, 5-gh] purines from 2-(Purin-6-yl)-2- …

C Temple Jr, JA Montgomery

Index: Temple,C.; Montgomery,J.A. Journal of Organic Chemistry, 1966 , vol. 31, p. 1417 - 1422

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Citation Number: 6

Abstract

Reaction of 6-chloropurine (1) with thiourea gave, in addition to purine-6 (lH)-thione (6), 2, 2- diamino-2H-thiazolo [3, 4, 5-gh] purine (14). 1-Ethyl-2-thiourea and 1 provided the corresponding ethyl derivative 15 of 14. From the reaction of 6-chloro-2-ethylpurine (2) and thiourea in propanol, 2-ethylpurine-6 (lH)-thione (8), 2, 2-diamino-7-ethyl-2H-thiazolo [3, 4, 5- gh] purine (13), and 2-ethyl-6-(propylthio) purine (1 1) were obtained, the formation of 11 ...