Synthesis and structure-activity relationships of novel benzimidazole and imidazo [4, 5-b] pyridine acid derivatives as thromboxane A2 receptor antagonists

…, T Benchetrit, JM Teulon, F Caussade…

Index: Nicolai, Eric; Goyard, Joel; Benchetrit, Thierry; Teulon, Jean-Marie; Caussade, Francois; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1176 - 1187

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Citation Number: 42

Abstract

Thromboxane Az (TXA2) is one of the predominant metabolites of arachidonic acid in various cells or tissues including platelets, lung, and Its potent constrictor effect on vascular smooth mu~ cles~~~ as its proaggregating action on platelets2~ 6 has been implicated in avariety of cardiovascular, renal, and respiratory disease^.^ Inhibition of biological effects of TXAz can be expected by inhibiting thromboxane synthesis or blocking TXAd PGHz ...