e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The Journal of organic chemistry
Tautomerism-dependent ring construction of N-heterocyclic compounds from the reactions of 1-alkynyl Fischer carbene complexes and substituted pyrazolinones
Four types of N-heterocyclic ring systems were successfully constructed from the reactions of 1-alkynyl Fischer carbene complexes (OC) 5M C (OEt) C⋮ CPh (1)(M= Cr, W) and substituted pyrazolinones (2). Reactions of 1 with 3-methyl-2-pyrazolin-5-one (2a), 3-n- propyl-2-pyrazolin-5-one (2b), 3, 4-dimethyl-2-pyrazolin-5-one (2c), 3, 4-trimethylene-2- pyrazolin-5-one (2d), or 3, 4-tetramethylene-2-pyrazolin-5-one (2e) generated three kinds ...