Tetrahedron letters

One-pot synthesis of α-bromoesters and ketones from β-ketoesters and diketones using supported reagents system

T Aoyama, T Takido, M Kodomari

Index: Aoyama, Tadashi; Takido, Toshio; Kodomari, Mitsuo Tetrahedron Letters, 2004 , vol. 45, # 9 p. 1873 - 1876

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Citation Number: 15

Abstract

A simple and efficient method has been developed for the synthesis of α-bromoesters and ketones from β-ketoesters and diketones in one pot using a supported reagents system, CuBr2/Al2O3–Na2CO3/Al2O3, in which β-ketoester reacts first with CuBr2/Al2O3 and the product, α-bromo-β-ketoester, reacts with Na2CO3/Al2O3 to give the final product, α- bromoesters in good yields.

~82%

~64%

~47%

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