Tetrahedron

Efficient and chemoselective direct reductive amination of aromatic aldehydes catalyzed by oxo–rhenium complexes containing heterocyclic ligands

…, PR Florindo, M Wolff, B Machura, AC Fernandes

Index: Bernardo, Joana R.; Sousa, Sara C.A.; Florindo, Pedro R.; Wolff, Mariusz; Machura, Barbara; Fernandes, Ana C. Tetrahedron, 2013 , vol. 69, # 43 p. 9145 - 9154

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Citation Number: 18

Abstract

Abstract This work describes the catalytic activity of 17 oxo–rhenium complexes containing heterocyclic ligands in the direct reductive amination of 4-nitrobenzaldehyde with 4- chloroaniline, using phenylsilane as reducing agent. In general, all of the catalysts tested gave excellent yields of the secondary amine, although, the best result was obtained with the catalytic system PhSiH 3/ReOBr 2 (Hhmpbta)(PPh 3)(2.5 mol%). This system was also ...