Structure–activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation

…, K Hattori, T Takashima, K Mizuno, M Mizutani…

Index: Kawai, Makoto; Sakurada, Isao; Morita, Asato; Iwamuro, Yuko; Ando, Kazuo; Omura, Hirofumi; Sakakibara, Sachiko; Masuda, Tsutomu; Koike, Hiroki; Honma, Teruki; Hattori, Kazunari; Takashima, Tadayuki; Mizuno, Kunihiko; Mizutani, Mayumi; Kawamura, Mitsuhiro Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 20 p. 5537 - 5542

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Citation Number: 7

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A novel potent NMDA-NR2B selective antagonist (5b) without the reactive metabolites formation issue was identified. Through this study, a close correlation between reactive metabolites formation and calculated HOMO energies of parent compounds was found.